Cephaeline Dihydrochloride ( —— )

产品货号. M31773 CAS No. 5853-29-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Cephaeline Dihydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
产品描述

(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
体外实验

CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC50s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (Ki) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield Kis of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.
体内实验

——
同义词

——
通路

Others
靶点

Other Targets
受体

——
研究领域

——
适应症

——

计算器

产品手册

关联产品

Zinquin ethyl ester

Zinquin ethyl ester 是 Zinquin 的荧光衍生物，是一种细胞锌荧光探针。Zinquin ethyl ester 能够穿透细胞膜，具有亲脂性、锌敏感性。Zinquin ethyl ester 在 Ca2+ 和 Mg2+ 存在的条件下可与 Zn2+ 结合，产生蓝色荧光。。
Ledene

Ledene 是一种由 viridiflorene 合成酶产生的精油。它已被研究作为抗菌剂、抗氧化剂、抗生物膜以及治疗各种癌症。
6-Hydroxygenistein

6-Hydroxygenistein is an isoflavonoid compound that can be found in Baptisia hirsuta and serves as a key precursor for the synthesis of various methylated isoflavonoids.